Reaktion #50002

Reaktionsgleichung

2,4-Dichloro-6-fluorobenzothiazole

nitric acid

→

2,4-dichloro-6-fluoro-7-nitrobenzothiazole

Lösungsmittel

sulfuric acid

sulfuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo this was added very slowly
2. 2
   Filtrationthe resulting crystals filtered off
3. 3
   Waschenwashed with water until neutral and
4. 4
   Sonstigedried in vacuo

Vorschrift

23.7 g 2,4-Dichloro-6-fluorobenzothiazole was dissolved in 100 ml concentrated sulfuric acid and the solution cooled to 0° C. To this was added very slowly, dropwise, a cooled solution of 14 ml concentrated sulfuric acid and 14 ml 100% nitric acid. The mixture was stirred for 3 hours, poured into 500 ml ice water, the resulting crystals filtered off, washed with water until neutral and dried in vacuo. Yield: 22.7 g=79% of theory m.p.: 110°-112° C.

Quelle