Reaktion #499774

Reaktionsgleichung

4-(2-amidino-8-chloronaphthalen-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride

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title compound

Ausbeute 132.5%

4-(2-Amidino-8-chloronaphthalen-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic Acid Dihydrochloride

Ausbeute 132.5%

Lösungsmittel

hydrochloric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Sonstigethe solvent was evaporated
3. 3
   Sonstigethe obtained residue was separated by HPLC (0.05% aqueous trifluoroacetic acid:methanol=1:1)
4. 4
   workup.ADDITIONThe obtained residue was treated with hydrogen chloride-ethanol
5. 5
   Sonstigedried under reduced pressure

Vorschrift

A solution of 4-(2-amidino-8-chloronaphthalen-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride (78 mg) in conc. hydrochloric acid was stirred at 50° C.-100° C. for 3 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was separated by HPLC (0.05% aqueous trifluoroacetic acid:methanol=1:1). The obtained residue was treated with hydrogen chloride-ethanol and dried under reduced pressure to give the title compound (49 mg).

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