Reaktion #499707

Reaktionsgleichung

1-(pyridin-4-yl)-4-(1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidine-4-carboxylic acid ethyl ester

diisopropylethylamine

1H-pyrazole-1-carboxamidine hydrochloride

→

title compound

Ausbeute 0.9%

4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic Acid Ethyl Ester Dihydrochloride

Ausbeute 0.9%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated and to the obtained residue
2. 2
   workup.ADDITIONwas added diethyl ether (350 ml)
3. 3
   Sonstigethe supernatant was removed
4. 4
   workup.DISSOLUTIONThe obtained oil was dissolved in methanol (20 ml)
5. 5
   workup.STIRRINGwith stirring
6. 6
   SonstigeThe supernatant was removed
7. 7
   Sonstigedried under reduced pressure
8. 8
   workup.DISSOLUTIONFifty (50) mg from the obtained 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester (10.0 g) was dissolved in ethanol
9. 9
   workup.ADDITIONdil. hydrochloric acid was added
10. 10
    EinengenThe mixture was concentrated
11. 11
    Sonstigedried under reduced pressure

Vorschrift

To a solution of 1-(pyridin-4-yl)-4-(1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidine-4-carboxylic acid ethyl ester (8.29 g) in dimethylformamide (50 ml) were added diisopropylethylamine (4.4 ml) and 1H-pyrazole-1-carboxamidine hydrochloride (3.69 g), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated and to the obtained residue was added diethyl ether (350 ml) and the supernatant was removed. The obtained oil was dissolved in methanol (20 ml) and thereto was dropwise added diethyl ether (700 ml) with stirring. The supernatant was removed and dried under reduced pressure. Fifty (50) mg from the obtained 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester (10.0 g) was dissolved in ethanol and dil. hydrochloric acid was added. The mixture was concentrated and dried under reduced pressure to give the title compound (55 mg).

Quelle