Reaktion #4995

Reaktionsgleichung

3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

aluminum isopropoxide

→

desired product

Ausbeute 54.0%

3-(1-hydroxybutyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

Ausbeute 54.0%

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturto reflux for 48 hours
3. 3
   SonstigeAfter evaporation of isopropanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ExtraktionThe aqueous solution was extracted with ethylacetate
6. 6
   SonstigeAfter evaporation of ethylacetate
7. 7
   Sonstigethe residue was purified by column chromatography(hexane: ethylacetate=3:2)

Vorschrift

0.316 g of 3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.20 g of aluminum isopropoxide were added to 10 ml of isopropanol. The mixture was heated to reflux for 48 hours. After evaporation of isopropanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane: ethylacetate=3:2) to provide 0.17 g of the desired product(yield: 54.0%).

Quelle