Reaktion #499372

Reaktionsgleichung

HCl

product

Methyl 4-Bromo-7-[(methanesulfonyl)oxy]naphthoate

NaOH

→

titled product

4-Bromo-7-hydroxynaphthoic Acid

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction was heated
2. 2
   Temperaturat reflux overnight
3. 3
   Extraktionextracted with 3× EtOAc
4. 4
   TrocknenThe combined organic extracts were dried over Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo
7. 7
   Sonstigeto give a solid, which
8. 8
   Sonstigewas triturated with dichloromethane

Vorschrift

To a solution of the the product from Step F (802 mg, 2.23 mmol) in 50 mL of THF was added 10 mL of 2N NaOH solution, and the reaction was heated at reflux overnight. The solution was acidified with 1N HCl and extracted with 3× EtOAc. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give a solid, which was triturated with dichloromethane to give the titled product.

Quelle