Reaktion #49936

Reaktionsgleichung

2,5-dichlorothiophene-3-carbonylchloride

Water

sodium hydroxide

N'-t-butyl-N-4-methylbenzoylhydrazine

→

N'-t-butyl-N-(4-methylbenzoyl)-N'-(2,5-dichlorothiophene-3-carbonyl)hydrazine

Lösungsmittel

ether

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer separated
2. 2
   SonstigeEvaporation
3. 3
   Sonstigeafforded a solid which
4. 4
   Sonstigewas triturated with 10% ether-hexane

Vorschrift

N'-t-butyl-N-4-methylbenzoylhydrazine (0.7 g) was dissolved in 35 ml toluene. Water (5 ml) and 50% aqueous sodium hydroxide (0.8 g) were added followed by 2,5-dichlorothiophene-3-carbonylchloride (2.0 g). After stirring for 3 hours at room temperature, ether was added and the organic layer separated. Evaporation afforded a solid which was triturated with 10% ether-hexane to afford N'-t-butyl-N-(4-methylbenzoyl)-N'-(2,5-dichlorothiophene-3-carbonyl)hydrazine: m.p. 163°-165° C.

Quelle