Reaktion #499246

ord-479e1379c7174a21a6b27c0e17ecb0a0

Reaktionsgleichung

COC(=O)c1cccnc1Cl
methyl 2-chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
C1COCCOCCOCCOCCOCCO1
18-crown-6

Edukte

COC(=O)c1cccnc1Cl
methyl 2-chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3.4 g of methyl 2-chloronicotinate were reacted with 3.4 g of 4-piperidinopideridine in 75 ml of DMF in the presence of 5.5 g of potassium carbonate and a spatula tipful of 18-crown-6 analogously to Example 1a, 5.9 g (97%) of the product being obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06562827B1uspto-grants-2003_05