Reaktion #499243

ord-db759a24a04441af8763a76023778cd3

Reaktionsgleichung

COC(=O)c1cccnc1Cl
methyl 2-chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
c1ccc(CN2CCNCC2)cc1
N-benzylpiperazine
→
COC(=O)c1cccnc1N1CCN(Cc2ccccc2)CC1
Methyl 2-(4-Benzylpiperazin-1-yl)nicotinate

Edukte

—
product
COC(=O)c1cccnc1Cl
methyl 2-chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
c1ccc(CN2CCNCC2)cc1
N-benzylpiperazine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigebeing obtained

Vorschrift

3.4 g of methyl 2-chloronicotinate, 5.5 g of potassium carbonate and 3.5 g of N-benzylpiperazine were reacted in 75 ml of DMF analogously to Example 1a, 6.2 g (100%) of the product being obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06562827B1uspto-grants-2003_05