Reaktion #499242

ord-f25a856c40ea47d88c92a75f8e1b53eb

Reaktionsgleichung

COC(=O)c1cccnc1Cl
methyl chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
Cl.Cl.c1cnc(N2CCNCC2)nc1
N-(2-pyrimidyl)piperazine dihydrochloride
→
COC(=O)c1cccnc1N1CCN(c2ncccn2)CC1
Methyl 2-(4-(Pyrimid-2-yl)piperazin-1-yl)nicotinate

Edukte

—
product
COC(=O)c1cccnc1Cl
methyl chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
Cl.Cl.c1cnc(N2CCNCC2)nc1
N-(2-pyrimidyl)piperazine dihydrochloride

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigebeing obtained

Vorschrift

3.4 g of methyl chloronicotinate, 11.1 g of potassium carbonate and 4.7 g of N-(2-pyrimidyl)piperazine dihydrochloride were reacted in 75 ml of DMF analogously to Example 1a, 4.6 g (78%) of the product being obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06562827B1uspto-grants-2003_05