Reaktion #499241

ord-15ddcc34377d4837ac9358dfcef4e53e

Reaktionsgleichung

COC(=O)c1cccnc1Cl
methyl chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CN1CCNCC1
N-methylpiperazine
→
COC(=O)c1cccnc1N1CCN(C)CC1
Methyl 2-(4-Methylpiperazin-1-yl)nicotinate

Edukte

—
product
COC(=O)c1cccnc1Cl
methyl chloronicotinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CN1CCNCC1
N-methylpiperazine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigebeing obtained

Vorschrift

3.4 g of methyl chloronicotinate, 5.5 g of potassium carbonate and 2.0 g of N-methylpiperazine were reacted in 50 ml of DMF analogously to Example 1a, 3.9 g (82%) of the product being obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06562827B1uspto-grants-2003_05