Reaktion #499240

Reaktionsgleichung

methyl chloronicotinate

potassium carbonate

4-pyridylpiperazine

18-crown-6

→

product

Ausbeute 82.0%

Methyl 2-(4-(Pyrid-4-yl)piperazin-1-yl)nicotinate

Ausbeute 82.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe excess potassium carbonate was filtered off
2. 2
   Einengenthe filtrate was concentrated
3. 3
   Sonstigethe residue was partitioned between water and ethyl acetate
4. 4
   TrocknenAfter drying the organic phase over magnesium sulfate
5. 5
   Einengenconcentrating the solvent

Vorschrift

3.4 g of methyl chloronicotinate, 5.5 g of potassium carbonate, 3.3 g of 4-pyridylpiperazine and a spatula tipful of 18-crown-6 were heated at 100° C. for 5 h in 75 ml of DMF and then stirred at room temperature for 60 h. The excess potassium carbonate was filtered off, the filtrate was concentrated and the residue was partitioned between water and ethyl acetate. After drying the organic phase over magnesium sulfate and concentrating the solvent, 3.9 g (82%) of the product were obtained.

Quelle