Reaktion #49918

Reaktionsgleichung

sodium hydroxide

t-butylhydrazine hydrochloride

benzoyl chloride

sodium hydroxide

→

N'-t-butyl-N-benzoylhydrazine

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefrom separate
2. 2
   workup.ADDITIONaddition funnels
3. 3
   Temperaturwhile maintaining the temperature at or below 10° C
4. 4
   workup.ADDITIONthe addition
5. 5
   Temperaturthe reaction mixture was warmed to room temperature
6. 6
   workup.ADDITIONThe reaction mixture was diluted with hexane

Vorschrift

To a stirred suspension of t-butylhydrazine hydrochloride (2 g, 0.016M) in toluene (50 ml) at room temperature was added dropwise a 50% aqueous solution of sodium hydroxide (1.28 g, 0.016M). After 15 minutes, the reaction mixture was cooled to 5° C. and a solution of benzoyl chloride (2.3 g, 0.017M) in toluene (5 ml) and a solution of aqueous 50% sodium hydroxide (1.36 g, 0.017M) were added dropwise simultaneously from separate addition funnels while maintaining the temperature at or below 10° C. Following the addition, the reaction mixture was warmed to room temperature and stirred for 1 hour. The reaction mixture was diluted with hexane and the solid N'-t-butyl-N-benzoylhydrazine was isolated by filtration.

Quelle