Reaktion #499170

Reaktionsgleichung

thiomorpholin-3-one

4-trifluoromethyl-1-iodobenzene

→

title product

Ausbeute 23.3%

4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one

Ausbeute 23.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue was then purified by flash chromatography

Vorschrift

A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.

Quelle