Reaktion #49914

Reaktionsgleichung

1-t-butyl-1-benzoylhydrazine

3-chloro-2,2-dimethylpropionylchloride

sodium hydroxide

→

N'-t-butyl-N-(beta-chloropivaloyl)-N'-benzoylhydrazine

Lösungsmittel

toluene

hexane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto maintain the temperature below 10° C

Vorschrift

To a stirred solution of 1-t-butyl-1-benzoylhydrazine (1 g, 0.005M) in toluene (40 ml) cooled to 5° C. was added 3-chloro-2,2-dimethylpropionylchloride (1.2 g, 0.007M) and 50% aq. sodium hydroxide (0.45 g, 0.0056M) so as to maintain the temperature below 10° C. The mixture was warmed to room temperature and stirred 1 hour. The mixture was diluted with hexane (40 ml) and water (10 ml). The white solid product N'-t-butyl-N-(beta-chloropivaloyl)-N'-benzoylhydrazine was isolated by suction filtration, washed with 50 ml hexane and 50 ml water and dried.

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