Reaktion #49840

Reaktionsgleichung

HCl

EtMgBr

m-tolunitrile

Et2O

benzene

→

ketone

3-Methylpropiophenone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 0° C.
2. 2
   Temperaturthe resulting mixture was cooled to 0° C
3. 3
   SonstigeThe organic phase was separated
4. 4
   Waschenwashed with 5% NaHCO3 and brine
5. 5
   Trocknendried (MgSO4)
6. 6
   Sonstigeevaporated

Vorschrift

To a 0° C. solution of EtMgBr in Et2O (3.0M, 570 mL, Aldrich) was slowly added m-tolunitrile (102 mL, Aldrich). After stirring at r.t. for 19 hr., benzene (300 mL) was added and the resulting mixture was cooled to 0° C. HCl (6N, 600 mL) was then slowly added. The organic phase was separated, washed with 5% NaHCO3 and brine, dried (MgSO4) and evaporated to afford the desired ketone as a yellow liquid.

Quelle