Reaktion #49828

Reaktionsgleichung

citric acid

pyridine

3-(7-Amino-1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazol-3-yl) -2-cyano-3-oxo-N-phenyl-propanamide

→

2-cyano-3-(7-ethoxalylamino -1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazol-3-yl) -3-oxo-N-phenyl-propanamide

Lösungsmittel

—

ice water

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate is filtered
2. 2
   Waschenwashed with water
3. 3
   SonstigeCrystallization from CHCl3 /ethanol

Vorschrift

3-(7-Amino-1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazol-3-yl) -2-cyano-3-oxo-N-phenyl-propanamide (1.1 g) dissolved in anhydrous dimethylformamide (70 ml) containing pyridine (1 ml) is reacted with ethyl oxalyl chloride (0.7 g) under stirring at room temperature for 6 hours. The reaction mixture is diluted with ice water and acidified to pH 4 with citric acid. The precipitate is filtered and washed with water. Crystallization from CHCl3 /ethanol yields 1.1 g of 2-cyano-3-(7-ethoxalylamino -1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazol-3-yl) -3-oxo-N-phenyl-propanamide.

Quelle