Reaktion #49801

Reaktionsgleichung

{o-[5-(2,4-dichlorophenoxy)-2nitrophenoxy]phenoxy}acetyl chloride

ammonia

ethanol

N,N-dimethylformamide

→

title product

2-{o-[5-(2,4-Dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetamide

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with an ether/ethyl acetate (1:1) solution
2. 2
   WaschenThe combined organic extracts are washed sequentially with water and brine
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A mixture of {o-[5-(2,4-dichlorophenoxy)-2nitrophenoxy]phenoxy}acetyl chloride (1.11 g, 2.38 mmol), ammonia solution (5 mL of a 35% solution), ethanol (5 mL) and N,N-dimethylformamide (10 mL) is stirred for one hour, poured into water and extracted with an ether/ethyl acetate (1:1) solution. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

Quelle