Reaktion #49774

ord-8659f9de01c24babaeff84e03d16e14d

Reaktionsgleichung

CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NC(=O)OCc1ccccc1
Z-DCha-Pro-OtBu
→
CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CC1CCCCC1
H-DCha-Pro-OtBu
Ausbeute 100.0%

Edukte

CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NC(=O)OCc1ccccc1
Z-DCha-Pro-OtBu

Reagenzien

[Pd]
Pd-C

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationFiltration and evaporation

Vorschrift

Z-DCha-Pro-OtBu (made by standard peptide coupling reactions) was hydrogenated in THF over 5% Pd-C at standard temperature and pressure for 24 h. Filtration and evaporation provided H-DCha-Pro-OtBu (oil, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05424291uspto-grants-1995_06