Reaktion #49746

Reaktionsgleichung

2-Fluoro-4-chloro-5-cyclopentyloxyphenylhydrazine

2-ethoxycarbonylcyclohexanone

→

(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-one

Ausbeute 72.3%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile heating
2. 2
   Temperaturunder refluxing
3. 3
   SonstigeAfter completion of the reaction
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   Sonstigeto obtain a crude product (37 g)
6. 6
   WaschenThe product was washed with a mixed solvent of benzene/hexane

Vorschrift

2-Fluoro-4-chloro-5-cyclopentyloxyphenylhydrazine (24.5 g, 0.10 mol), 2-ethoxycarbonylcyclohexanone (17.0 g, 0.10 mol) were dissolved in acetic acid (200 ml), and stirred for 2 hours while heating under refluxing. After completion of the reaction, the solvent was distilled off to obtain a crude product (37 g). The product was washed with a mixed solvent of benzene/hexane to obtain 2N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-one as a white solid (25.3 g, 72.3% yield)

Quelle