Reaktion #49724

Reaktionsgleichung

5-[3-chloro-4-(methylsulphenyl)phenyl]-4-cyclopropylcarbonyl-isoxazole

3-chloroperoxybenzoic acid

sodium bisulphite

→

4-cyclopropylcarbonyl-5-[3-chloro-4-(methylsulphonyl)phenyl]isoxazole

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe layers were separated
2. 2
   WaschenThe organic phase was washed with sodium bicarbonate solution, water
3. 3
   Trocknendried (MgSO4)
4. 4
   Filtrationfiltered
5. 5
   SonstigeThe flitrate was evaporated to dryness

Vorschrift

A mixture of 5-[3-chloro-4-(methylsulphenyl)phenyl]-4-cyclopropylcarbonyl-isoxazole (1.0g) and 3-chloroperoxybenzoic acid (2.3g, 50%) in dichloromethane was stirred overnight. A saturated solution of sodium bisulphite was added and the layers were separated. The organic phase was washed with sodium bicarbonate solution, water, dried (MgSO4) and filtered. The flitrate was evaporated to dryness to give 4-cyclopropylcarbonyl-5-[3-chloro-4-(methylsulphonyl)phenyl]isoxazole (compound 5, 1.11g) as a white solid, m.p. 148°-150° C.

Quelle