Reaktion #49720

Reaktionsgleichung

benzyl 2-(2,6-dimethoxypyrimidine-4-yloxy)-6-phenylbenzoate

hydrogen

→

2-(2,6-dimethoxypyrimidine-4-yloxy)-6-phenylbenzoic acid

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe palladium on carbon was filtered off
2. 2
   Sonstigethe filtrate obtained
3. 3
   Einengenwas concentrated under reduced pressure

Vorschrift

To 10.3 Grams of benzyl 2-(2,6-dimethoxypyrimidine-4-yloxy)-6-phenylbenzoate dissolved in 100 ml of ethyl acetate was added 0.5 g of 10% palladium on activated carbon (water content: about 50%) and the resulting mixture was subjected to catalytic reduction at room temperature under normal pressure (hydrogen pressure) for 3 hours. The palladium on carbon was filtered off and the filtrate obtained was concentrated under reduced pressure to obtain 2-(2,6-dimethoxypyrimidine-4-yloxy)-6-phenylbenzoic acid (the present compound (1)) in quantitative yield.

Quelle