Reaktion #497067

Reaktionsgleichung

1-Boc-3-aminoazetidine

Et3N

benzoyl chloride

→

compound 1c

Ausbeute 98.5%

tert-Butyl 3-benzamidoazetidine-1-carboxylate

Ausbeute 98.5%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched with aq. NaHCO3
2. 2
   Extraktionthe resulting mixture was extracted with CH2Cl2
3. 3
   TrocknenThe organic solution was dried over Na2SO4
4. 4
   Einengenconcentrated
5. 5
   SonstigePurification by flash column chromatography (silica gel, 40% EtOAc/heptane)

Vorschrift

To a solution of 1-Boc-3-aminoazetidine 1a (1.2 g, 6.98 mmol) and Et3N (2.4 mL, 17.3 mmol) in CH2Cl2 (70 mL) at 0° C. was added benzoyl chloride 1b (0.89 mL, 7.68 mmol). The reaction was kept at 0° C. for 3 h, quenched with aq. NaHCO3, and the resulting mixture was extracted with CH2Cl2. The organic solution was dried over Na2SO4 and concentrated. Purification by flash column chromatography (silica gel, 40% EtOAc/heptane) gave compound 1c (1.9 g).

Quelle