Reaktion #4968

Reaktionsgleichung

4-ethoxyphenylacetylene

3,4-difluoroiodobenzene

triethylamine

→

3,4-difluoro-4'-ethoxytolan

Lösungsmittel

methyl tert.-butyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered with suction
2. 2
   Sonstigethe solution is evaporated
3. 3
   SonstigePurification
4. 4
   Sonstigeby chromatography and/or crystallization

Vorschrift

0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.

Quelle