Reaktion #496429

ord-cc1294e7907449029c87193c6375160b

Reaktionsgleichung

COC(=O)c1nc(C#N)c2cc(Cc3ccccc3)ccc2c1O
7-benzyl-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine
→
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Cc3ccccc3)cc12
title compound
N#Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Cc3ccccc3)cc12
[(7-Benzyl-1-cyano-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid

Edukte

COC(=O)c1nc(C#N)c2cc(Cc3ccccc3)ccc2c1O
7-benzyl-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized from 7-benzyl-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester and glycine in analogy to example 1b; MS-(−)-ion: M−1=360.5.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08759373B2uspto-grants-2014_06