Reaktion #496428

ord-c97270ccafc54dd8818aad6a623f1add

Reaktionsgleichung

COC(=O)c1nc(Br)c2cc(Cc3ccccc3)ccc2c1O
7-benzyl-1-bromo-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN
→
COC(=O)c1nc(C#N)c2cc(Cc3ccccc3)ccc2c1O
title compound
COC(=O)c1nc(C#N)c2cc(Cc3ccccc3)ccc2c1O
7-Benzyl-1-cyano-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester

Edukte

COC(=O)c1nc(Br)c2cc(Cc3ccccc3)ccc2c1O
7-benzyl-1-bromo-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized from 7-benzyl-1-bromo-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(−)-ion: M−1=317.4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08759373B2uspto-grants-2014_06