Reaktion #496423

ord-5296ef51521d468ba17c552a1f126031

Reaktionsgleichung

COC(=O)c1nc(Br)c2c(Oc3ccccc3OC)cccc2c1O
1-bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN
→
COC(=O)c1nc(C#N)c2c(Oc3ccccc3OC)cccc2c1O
title compound
COC(=O)c1nc(C#N)c2c(Oc3ccccc3OC)cccc2c1O
1-Cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester

Edukte

COC(=O)c1nc(Br)c2c(Oc3ccccc3OC)cccc2c1O
1-bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
N#[C][Cu]
CuCN

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized from 1-bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(+)-ion: M+1=351.4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08759373B2uspto-grants-2014_06