Reaktion #496420

ord-768e7cd3808e4044b62531585cca903f

Reaktionsgleichung

COC(=O)c1nc(C#N)c2c(Oc3cccc(OC)c3)cccc2c1O
1-cyano-4-hydroxy-8-(3-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine
→
COc1cccc(Oc2cccc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c23)c1
title compound
COc1cccc(Oc2cccc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c23)c1
{[1-Cyano-4-hydroxy-8-(3-methoxy-phenoxy)-isoquinoline-3-carbonyl]-amino}-acetic acid

Edukte

COC(=O)c1nc(C#N)c2c(Oc3cccc(OC)c3)cccc2c1O
1-cyano-4-hydroxy-8-(3-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized from 1-cyano-4-hydroxy-8-(3-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and glycine in analogy to example 1b; MS-(−)-ion: M−1=392.4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08759373B2uspto-grants-2014_06