Reaktion #496418

ord-adb41717de9a42bc94c8adb4d89ca7ed

Reaktionsgleichung

COC(=O)c1nc(C#N)c2c(Oc3ccc(OC)cc3)cccc2c1O
1-cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine
→
COc1ccc(Oc2cccc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c23)cc1
title compound
COc1ccc(Oc2cccc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c23)cc1
{[1-Cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carbonyl]-amino}-acetic acid

Edukte

COC(=O)c1nc(C#N)c2c(Oc3ccc(OC)cc3)cccc2c1O
1-cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
NCC(=O)O
glycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized from 1-cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and glycine in analogy to example 1b; MS-(−)-ion: M−1=392.4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08759373B2uspto-grants-2014_06