Reaktion #49621

Reaktionsgleichung

2-chloro-5-methylnicotinic acid

EDCI

HOBT monohydrate

cumylamine

→

2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide

Ausbeute 62.0%

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated solid was collected by filtration
2. 2
   Sonstigedried under reduced pressure

Vorschrift

In a similar manner to Step 1 of Example 137, 2-chloro-5-methylnicotinic acid (2.00 g, 11.7 mmol) was dissolved in DMF (40 mL), and the solution was treated with EDCI (3.35 g, 17.5 mmol), HOBT monohydrate (890 mg, 5.83 mmol) and cumylamine (3.40 mL, 23.3 mmol). The mixture was added with water. The precipitated solid was collected by filtration and dried under reduced pressure to obtain 2-chloro-6-methyl-N-(1-methyl-1-phenylethyl)nicotinamide (2.09 mg, yield 62%).

Quelle