Reaktion #49620

Reaktionsgleichung

trifluoroacetic acid

triethylsilane

hexane ethyl acetate

4,7-dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

→

4,7-dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

Ausbeute 72.0%

Lösungsmittel

nitromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

in a similar manner to Step 4 of Example 16, 4,7-dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (38.8 mg, 0.115 mmol) was dissolved in nitromethane (1.6 mL), and the solution was treated with trifluoroacetic acid (0.177 mL, 2.30 mmol) and triethylsilane (55.1 mL, 0.345 mmol), followed by purification by slurry using chloroform/methanol and by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain 4,7-dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (16.8 mg, yield 72%).

Quelle