Reaktion #49607

Reaktionsgleichung

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

triethylamine

ethyl isocyanate

→

4-chloro-5-[3-(ethylcarbamoylamino)propoxy]-7-iodoisoindolinone

Ausbeute 93.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe residue was purified by slurry

Vorschrift

4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (100 mg, 0.248 mmol) was suspended in dichloromethane (3.0 mL), and the suspension was added with triethylamine (0.104 mL, 0.744 mmol) and ethyl isocyanate (0.029 mL, 0.372 mmol), followed by stirring at room temperature for 13 hours. The solvent was evaported under reduced pressure and the residue was purified by slurry using water and acetonitrile to obtain 4-chloro-5-[3-(ethylcarbamoylamino)propoxy]-7-iodoisoindolinone (100 mg, yield 93%).

Quelle