Reaktion #49601

Reaktionsgleichung

4-Chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone

hydrogen chloride methanol

diisopropylether

→

4-chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

Ausbeute 193.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe obtained solid was collected by filtration
2. 2
   Waschenwashed with diisopropylether
3. 3
   Sonstigeby drying under reduced pressure

Vorschrift

4-Chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone (101 mg, 0.216 mmol) was suspended in methanol (1.5 mL), and the suspension was added with 10% hydrogen chloride-methanol solution (1.5 mL), followed by stirring at 60° C. for 1.0 hour. The reaction mixture was added with diisopropylether. The obtained solid was collected by filtration and washed with diisopropylether, followed by drying under reduced pressure to obtain 4-chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (84.0 mg, yield 96%).

Quelle