Reaktion #49600

Reaktionsgleichung

4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

(4-bromo-2-methyl-2-butoxy)triethylsilane

→

4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone

Ausbeute 35.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by flash column chromatography (chloroform/methanol=99/1)

Vorschrift

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).

Quelle