Reaktion #495983

Reaktionsgleichung

2-Ethylpyrazolo[1,5-a]pyridine

acetic acid

N-iodosuccinimide

→

desired compound

Ausbeute 93.0%

2-Ethyl-3-iodopyrazolo[1,5-a]pyridine

Ausbeute 93.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   Sonstigepurified on silica gel with ethyl acetate in hexanes (0-15%)

Vorschrift

2-Ethylpyrazolo[1,5-a]pyridine (4.1 g, 22 mmol) was stirred in acetic acid (2.6 g, 18 mmol) and N-iodosuccinimide (8 g, 40 mmol) was added in portions over 5 hrs. The mixture was evaporated and purified on silica gel with ethyl acetate in hexanes (0-15%) to give the desired compound (4.5 g, 93%). LCMS for C9H10N2 (M+H)+: m/z=273.1. 1H NMR (300 MHz, DMSO-d6): δ 8.62 (m, 1H), 7.40 (m, 1H), 7.27 (m, 1H), 6.82 (m, 1H), 2.72 (m, 2H), 1.22 (m, 3H).

Quelle