Reaktion #49578

Reaktionsgleichung

water

triethylamine

2-pyridinesulfonyl chloride hydrochloride

4-Hydroxy-5-methoxy-7-iodoisoindolinone

→

4-(2-pyridinesulfonyloxy)-5-methoxy-7-iodoisoindolinone

Ausbeute 69.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred at room temperature for 30 minutes
2. 2
   FiltrationThe precipitated crystal was collected by filtration

Vorschrift

4-Hydroxy-5-methoxy-7-iodoisoindolinone (0.465 g, 1.52 mmol) was dissolved in acetonitrile (10.0 mL), and the solution was added with triethylamine (0.850 mL, 6.09 mmol) and 2-pyridinesulfonyl chloride hydrochloride (0.488 g, 2.28 mmol), followed by stirring at room temperature for 5 hours. The reaction mixture was added with water (8.0 mL) and stirred at room temperature for 30 minutes. The precipitated crystal was collected by filtration to obtain 4-(2-pyridinesulfonyloxy)-5-methoxy-7-iodoisoindolinone (0.468 g, yield 69%).

Quelle