Reaktion #49552

Reaktionsgleichung

EDCI

HOBT monohydrate

cumylamine

3-methoxymethoxy-4-methylbenzoic acid

→

3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

Ausbeute 83.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

In a similar manner to Step 1 of Example 137, 3-methoxymethoxy-4-methylbenzoic acid (2.69 g) was dissolved in DMF (53 mL), and the solution was treated with EDCI (5.04 g, 26.3 mmol), HOBT monohydrate (2.01 g, 13.1 mmol) and cumylamine (3.80 mL, 26.4 mmol), followed by purification by slurry using hexane to obtain 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (3.42 g, yield 83%, 2 steps).

Quelle