Reaktion #495440

Reaktionsgleichung

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpyrrolidine-1-carboxylate

→

tert-butyl 3-methylpyrrolidin-3-ylcarbamate

Ausbeute 96.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration
2. 2
   Waschenwashed with methanol
3. 3
   EinengenThe filtrate was concentrated

Vorschrift

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpyrrolidine-1-carboxylate (2.00 g, 5.98 mmol) and 10% Pd/C (0.32 g, 0.30 mmol) in MeOH (20 mL) were stirred under 1 atmosphere of H2 for 1 hour. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to give tert-butyl 3-methylpyrrolidin-3-ylcarbamate (1.15 g, 96%) as a solid.

Quelle