Reaktion #49539

Reaktionsgleichung

4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

hydrogen chloride methanol

→

4-chloro-5-hydroxy-7-iodoisoindolinone

Ausbeute 58.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

In a similar manner to Step 6 of Example 139, 4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (97.1 mg, 0.206 mmol) was treated with 10% hydrogen chloride-methanol solution (3 mL), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-hydroxy-7-iodoisoindolinone (36.9 mg, yield 58%).

Quelle