Reaktion #49535

Reaktionsgleichung

3-chloro-4-methoxymethoxybenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-chloro-4-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide

Ausbeute 77.1%

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated solid was collected by filtration
2. 2
   Waschenwashed with water
3. 3
   Sonstigeby drying under reduced pressure

Vorschrift

In a similar manner to Step 1 of Example 137, 3-chloro-4-methoxymethoxybenzoic acid (2.39 g, 11.0 mmol) was dissolved in DMF (47 mL), and the solution was treated with EDCI (4.23 g, 22.1 mmol), HOBT monohydrate (1.69 g, 11.0 mmol) and cumylamine (3.20 mL, 22.0 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure to obtain 3-chloro-4-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide (2.83 g, yield 77%).

Quelle