Reaktion #495307

Reaktionsgleichung

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpiperidine-1-carboxylate

→

tert-butyl 3-methylpiperidin-3-ylcarbamate

Ausbeute 72.3%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration
2. 2
   Waschenwashed with methanol
3. 3
   EinengenThe filtrate was concentrated

Vorschrift

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpiperidine-1-carboxylate (1.4 g, 4.0 mmol) and 10% Pd/C (0.21 g, 0.2 mmol) in MeOH (20 mL) were stirred under H2 atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to give tert-butyl 3-methylpiperidin-3-ylcarbamate (0.62 g, 72% yield) as a solid.

Quelle