Reaktion #49525

Reaktionsgleichung

3-chloro-4-methylbenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

Ausbeute 97.2%

Lösungsmittel

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated solid was collected by filtration
2. 2
   Waschenwashed with water
3. 3
   Sonstigeby drying under reduced pressure
4. 4
   SonstigeThe obtained solid was purified by slurry

Vorschrift

In a similar manner to Step 1 of Example 137, 3-chloro-4-methylbenzoic acid (1.00 g, 5.86 mmol) was dissolved in DMF (20 mL), and the solution was treated with EDCI (2.25 g, 11.7 mmol), HOBT monohydrate (792 mg, 5.86 mmol) and cumylamine (1.69 mL, 11.7 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure. The obtained solid was purified by slurry using diisopropylether to obtain 3-chloro-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (1.64 g, yield 97%).

Quelle