Reaktion #49520

Reaktionsgleichung

3-hydroxy-4-chloro-5-fluoro-7-iodo-2(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-chloro-5-fluoro-7-iodoisoindolinone

Ausbeute 85.0%

Lösungsmittel

nitromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

In a similar manner to Step 4 of Example 16, 3-hydroxy-4-chloro-5-fluoro-7-iodo-2(1-methyl-1-phenylethyl)isoindolinone (806 mg, 1.81 mmol) was dissolved in nitromethane (32 mL), and the solution was treated with trifluoroacetic acid (1.40 mL, 18.1 mmol) and triethylsilane (0.578 mL, 3.62 mmol), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-fluoro-7-iodoisoindolinone (477 mg, yield 85%).

Quelle