Reaktion #49481

Reaktionsgleichung

7-amino-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone

potassium iodide

iodine

tert-butyl nitrate

→

7-iodo-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone

Ausbeute 52.1%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by flash column chromatography (chloroform)

Vorschrift

In a similar manner to Step 4 of Example 140, 7-amino-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone (115 mg, 0.324 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with potassium iodide (73.8 mg, 0.441 mmol), copper iodide (84.8 mg, 0.441 mmol), iodine (113 mg, 0.441 mmol) and tert-butyl nitrate (0.071 mL, 0.551 mmol), followed by purification by flash column chromatography (chloroform) to obtain 7-iodo-4-(3-tert-butyldimethylsilyloxyphenyl)isoindolinone (78.6 mg, yield 52%).

Quelle