Reaktion #494418

Reaktionsgleichung

Dimethyl 1-diazo-2-oxopropylphosphonate

methyl 4-amino-5-fluoro-6-(4-formylphenyl)-3-methoxypicolinate

K2CO3

CH3OH

→

title compound

Ausbeute 73.4%

methyl 4-amino-6-(4-ethynylphenyl)-5-fluoro-3-methoxypicolinate

Ausbeute 73.4%

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 20 mL reaction
2. 2
   Waschenwashed with 5% NaHCO3 (25 mL)
3. 3
   TrocknenThe organic layer was dried over MgSO4 (5 g)
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated on a rotary evaporator
6. 6
   SonstigeThe resulting residue was purified
7. 7
   Sonstigea Teledyne ISCO purification system with a gradient eluent system of CH2Cl2 and EtOAc

Vorschrift

To a 20 mL reaction vial were added methyl 4-amino-5-fluoro-6-(4-formylphenyl)-3-methoxypicolinate (0.41 g, 1.347 mmol), K2CO3 (0.372 g, 2.69 mmol), and CH3OH (20 mL). Dimethyl 1-diazo-2-oxopropylphosphonate (0.311 g, 1.617 mmol) was added in one portion. After stirring for 4 h, the reaction mixture was diluted with Et2O (50 mL) and washed with 5% NaHCO3 (25 mL). The organic layer was dried over MgSO4 (5 g), filtered, and concentrated on a rotary evaporator. The resulting residue was purified using a Teledyne ISCO purification system with a gradient eluent system of CH2Cl2 and EtOAc to yield the title compound as an off-white solid (297 mg, 73%): 1H NMR (400 MHz, CDCl3) δ 7.93-7.85 (m, 2H), 7.62-7.53 (m, 2H), 4.57 (s, 2H), 3.98 (s, 3H), 3.96 (s, 3H), 3.15 (s, 1H); 19F NMR (376 MHz, CDCl3) δ −139.97; ESIMS m/z 301 ([M+H]+), 299 ([M−H]−).

Quelle