Reaktion #493998

Reaktionsgleichung

2-chloro-4-phenylquinazoline

4-aminobenzoic acid

→

4-(4-phenylquinazolin-2-ylamino)benzoic acid

Lösungsmittel

2-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 4 h
2. 2
   Filtrationthe precipitate was collected by filtration
3. 3
   Waschenwashed with 2-propanol

Vorschrift

To a solution of 2-chloro-4-phenylquinazoline (9.6 g, 40 mmol) in 2-propanol (130 mL) was added 4-aminobenzoic acid (8.2 g, 60 mmol) and the mixture was stirred at reflux for 4 h. The mixture was cooled to rt and the precipitate was collected by filtration and washed with 2-propanol. The product, 4-(4-phenylquinazolin-2-ylamino)benzoic acid, was isolated as a yellow solid (12.9 g, 95%).

Quelle