Reaktion #49386

Reaktionsgleichung

4-chloro-7-(1-(tert-butoxycarbonyl)-indol-2-yl)isoindolinone

iodine

→

4-chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone

Ausbeute 36.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

In a similar manner to Step 1 of Example 161, 4-chloro-7-(1-(tert-butoxycarbonyl)-indol-2-yl)isoindolinone (374 mg, 0.980 mmol) was dissolved in ethanol (26 mL), and the solution was treated with iodine (299 mg, 1.18 mmol) and silver sulfate (306 mg, 0.980 mmol), followed by purification by slurry using hexane and diisopropylether to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]isoindolinone (179 mg, yield 36%).

Quelle