Reaktion #49381

Reaktionsgleichung

triethylamine

4-chloro-7-iodoisoindolinone

→

Compound 156

Ausbeute 164.2%

4-Chloro-7-(1-methylindol-2-yl)isoindolinone

Ausbeute 164.2%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1)

Vorschrift

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (84.0 mg, 0.286 mmol) was dissolved in acetonitrile (3 mL), and the solution was treated with Compound BK (100 mg, 0.571 mmol), palladium acetate (5.2 mg, 0.023 mmol) and triethylamine (0.400 mL, 2.87 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1) to obtain Compound 156 (69.7 mg, yield 82%).

Quelle