Reaktion #493779

Reaktionsgleichung

methylhydrazine

2,6-difluoroacetophenone

1,2-diethyl ethanedioate

sodium tert-butoxide

→

title compound

Ausbeute 12.5%

ethyl 5-(2,6-difluorophenyl)-1-methyl-1H-pyrazole-3-carboxylate

Ausbeute 12.5%

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITwas continued for 1 h
2. 2
   SonstigeThe reaction mixture was partitioned between hydrochloric acid (1 N) and diethyl ether
3. 3
   SonstigeThe organic phase was separated
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated under reduced pressure to half its original volume
7. 7
   workup.STIRRINGstirring
8. 8
   workup.WAITwas continued overnight
9. 9
   EinengenThe reaction mixture was concentrated under reduced pressure
10. 10
    Sonstigethe resulting material was purified by silica gel chromatography (5 to 20% gradient of ethyl acetate in methylene chloride as eluant)

Vorschrift

To a mixture of 2,6-difluoroacetophenone (4.7 g, 0.03 mol) and 1,2-diethyl ethanedioate (4.8 g, 0.033 mol) in ethanol (33 mL) was added sodium tert-butoxide (3.17 g, 0.033 mol). After 1 h, more ethanol (30 mL) was added to the reaction mixture and stirring was continued for 1 h. The reaction mixture was partitioned between hydrochloric acid (1 N) and diethyl ether. The organic phase was separated, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to half its original volume. To the resulting mixture was added methylhydrazine (1.52 g, 0.033 mol) and stirring was continued overnight. The reaction mixture was concentrated under reduced pressure and the resulting material was purified by silica gel chromatography (5 to 20% gradient of ethyl acetate in methylene chloride as eluant) to provide the title compound as a solid (1.0 g).

Quelle