Reaktion #49362

Reaktionsgleichung

3-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide

TMEDA

sec-butyllithium hexane

DMF

→

4-methoxymethoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

Ausbeute 96.2%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by slurry

Vorschrift

In a similar manner to Step 2 of Example 16, 3-methoxymethoxy-N-(1-methyl-1-phenylethyl)benzamide (8.07 g, 27.0 mmol) was dissolved in THF (320 mL), and the solution was treated with TMEDA (13.0 mL, 85.4 mmol), sec-butyllithium-hexane solution (0.99 mol/L, 87.1 mL, 86.3 mmol) and DMF (4.60 mL, 59.3 mmol), followed by purification by slurry using hexane to obtain 4-methoxymethoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (8.50 g, yield 96%).

Quelle