Reaktion #493589

Reaktionsgleichung

2-(4-Fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid

formamide

→

title compound

Ausbeute 83.0%

2-(4-Fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-ol

Ausbeute 83.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe excess formamide was removed by distillation
2. 2
   workup.ADDITIONWater was added
3. 3
   Filtrationthe precipitated product was filtered of

Vorschrift

2-(4-Fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid (29) (830 mg, 2.7 mmol) was heated to 150° C. in formamide (20 ml) for 4 h. The excess formamide was removed by distillation. Water was added and the precipitated product was filtered of to give pure title compound (642 mg, 83%).

Quelle